Electrophysiology

For cultured cells or cells in a monolayer they are most often viewed using an inverted microscope. In these instances the best manipulator is one that has orthogonal axes in XYZ and can provide a steep angle for the tip. For this application the recommend manipulators are the PCS-6200-C and the PCS-4100

There are numerous ways for the PCS-6200-C and PCS-4100 to be used either as a single unit or as combination unit.

Option 1: PCS-6200-C

Option 2: PCS-6200-C and a PCS-4100-N (in this combination the PCS-4100 would not need a power supply since it work from the power supplied with the 6200.)

Option 3: PCS-4100 and PCS-4100-N (both units will share the same power supply.)

PCS-6200-C Features	Benefits
25mm of motorized motion in three linear axes	Coarse positioning without touching the manipulator
150 µm of piezo motion in all three axes	Piezo motion provides ultra smooth positioning, essentially turning finger movements into nanometer precision
Drift specification of better than 1 µm per hour	Stable patching, providing results faster and with less frustration
Easy tip exchange made possible by two rotary stages with adjustable stops	Tip exchange can be accomplished rapidly and easily, in some cases saving as much as 90 minutes of recording time per day
XYZ axis	Position the tip over the cell with X and Y and patch using the Z-axis
Two year warranty	Peace of mind
Controller electronics will support a PCS-4100 manipulator	The additional manipulator can either be used for dual patching or for holding stimulating electrodes or perfusion pipettes

PCS-4100 is a fully featured cost effective manipulator that is precise enough for patching and in expensive enough to be used for holding stimulation electrodes and perfusion pipettes.

PCS-4100 Features	Benefits
25 mm of motion in three linear axes	Coarse positioning without touching the manipulator.
X and Y are manual and Z is motorized.	X and Y axes provide easy positioning whereas the Z-axis is used for making the patch.
Two user defined memory positions in Z (home and work for example)	Ease of use and augments easy tip exchange.
Easy tip exchange made possible by two rotary stages with adjustable stops.	Tip exchange can be accomplished rapidly and easily, in some cases saving as much as 90 minutes of recording time per day.
Electronics will support two PCS-4100 manipulators	Cost saving
Two year warranty	Peace of mind.